Current
Recommendations For Cats
Feline
injection site Fibrosarcoma
is a type of terminal
cancer related to inflammation caused by rabies and leukemia
vaccines.(12) This cancer is thought to affect 1 in 20,000 cats vaccinated.
Mean disease free interval time or survival time with surgical removal is
about 3 months. Mean survival time with surgical removal plus radiation
treatment plus chemotherapy is less than 3 years. Amputation of a rear leg
plus radiation has resulted in a few cures.
Vaccines with adjuvant, an
ingredient included to stimulate the immune system, have been implicated as
a higher risk, although other injectable drugs have been incriminated as
well. Adjuvanted vaccines have been demonstrated to induce mutation in
cell cultures. Adjuvanted Rabies, Distemper and
Feline Leukemia vaccines have been classified as Class II carcinogens by the
World Health Organization.
To
minimize the risk of injection site fibrosarcomas, we now recommend all
non-adjuvanted vaccines for cats, including Merial PCR Purevac rabies
vaccine. Testing by Dr. Dennis Macey, Colorado State University, has shown
this vaccine to have the lowest tissue reaction. Although there is no
guarantee that an injection site fibrosarcoma will not develop, the risk
will be much lower than with other vaccines.(12) After three years on the
market there have been only two injection site fibrosarcomas confirmed with
Purevac rabies vaccine vs. over 70,000 caused by adjuvanted rabies vaccines.
Dr Rogers was instrumental in getting the Texas Department of Public Health
and the New Mexico Department of Public Health to change the rabies
vaccination requirement effective March 2003 to :
Dogs and Cats should be vaccinated for rabies at
four months of age, one -year later, and subsequently every three years.
Alternatively, to prevent fibrosarcomas, cats can be vaccinated annually
with a non adjuvanted product with a one year duration of immunity.
This
law is retroactive. Patients vaccinated in 2002 are not due fro another
rabies vaccine until 2005.
Scientists agree
that three annual vaccinations with a non -adjuvanted rabies vaccine is
safer and less likely to cause a fibrosarcoma than one vaccination with a
three year DOI adjuvanted vaccine. Three year DOI Licensing for the Purevac
non-adjuvanted Rabies product is pending.
Program
injectable
six month flea prevention
for cats has been shown to be very tissue reactive and therefore has the
potential of inducing an injection site fibrosarcoma.(12) Droncit
injectable tapeworm medication also has the potential to be tissue
reactive in some cats.
***If your cat develops a lump at the site of a vaccination,
we highly recommend that it be removed ASAP, within 3-12 weeks, hopefully
before it becomes cancerous.
Feline
Leukemia Virus Vaccine:
Feline leukemia virus (FeLV) is the leading killer of cats. The virus is
spread from cat-to-cat through bite wounds, through extensive contact with
infected cats, and from an infected mother cat to her kittens. The
individuals most at risk of infection are young outdoor cats, young
indoor/outdoor cats, and young cats exposed to such individuals. Young cats
living in households with FeLV-infected cats or with cats of unknown
infection status are at risk. Indoor-only cats with no exposure to
potentially infected cats and adult cats are unlikely to become infected.
FeLV
vaccines are recommended for all cats less than 1 year of age at risk of
exposure to the virus and those cats of unpredictable futures.
Approximately
30 % of cats that are exposed to the FeLV virus have a transient viremia.
They are infected by the virus and they become naturally immune to the virus
and eliminate the infection. Unfortunately this transient viremia can cause
residual DNA damage which can cause a FeLV related cancer years later, the
so called "hit and run phenomena. We recommend Leucat non -adjuvanted
vaccine. Leucat FeLV vaccine is the effective in preventing transient
viremia.
Cats over
one year of age are naturally 89% immune to FeLV (age related resistance)
whether they are vaccinated or not, so annual vaccination of adult
cats is not necessary.(10, 15-p5, 21-p681,23-p239) Age related
immunity is actually better than vaccine induced immunity. (Cats infected at
a younger age can still incubate the disease and come down with Leukemia for
up to 8+ years.) (Some cats that are infected at a young age can
spontaneously become immune and get rid of the virus. This transient viremia
can cause residual DNA damage and result in FeLV related cancer years later
although the virus has long been gone.)
If your
cat is outside getting into fights and exposed to other cats you might want
to err on the side of caution and vaccinate for FeLV every three years with
a non- adjuvanted vaccine.
The
incubation period of Feline leukemia can be 3 -8 years, so if your cat is
in the incubation stage of the disease prior to vaccination, the vaccine
will not prevent the disease. We highly recommend testing every cat or
kitten for FeLV.
Feline
Panleukopenia Virus Vaccine:
Feline panleukopenia (also called feline distemper) is a highly contagious
and deadly viral disease of kittens. This disease is rare. Feline
panleukopenia virus is extremely hardy, is able to survive extremes of
temperature and humidity for many months, and is resistant to most available
disinfectants. Similar to canine parvovirus, it causes bloody, watery
diarrhea and is rapidly fatal. Although an effective treatment protocol is
available, it is expensive to treat. Because of the serious nature of the
disease and the continued presence of virus in the environment, vaccination
is highly recommended for all kittens. Cats vaccinated at 6 months of age or
older with will produce an immunity good for life.(15, 20, 21) Adult cats
do not need this vaccine. We recommend MLV non- adjuvanted vaccine.
Dr. Pedersen's Duration of Immunity Studies demonstrated immunity by
serology & challenge for 7 1/2 years after immunization.(24) This study was
reproduced by Dr Michael Lappin. Longer Duration of Immunity studies are
pending. Most immunologists feel the protection is lifelong.
Feline
Calici virus / Herpesvirus Vaccine:
Feline calicivirus and rhinotracheitis (feline herpes virus type I) are
responsible for 80-90% of infectious feline upper respiratory tract
diseases. Most cats are exposed to either or both of these viruses at some
time in their lives. Both indoor as well as outdoor cats are easily exposed
to this airborne virus. Once infected, many cats never completely rid
themselves of the virus. These "carrier" cats either continuously or
intermittently shed the organisms for long periods of time -- perhaps for
life -- and serve as a major source of infection to other cats. The
infection can also relapse with stress. The currently available vaccines
do not completely protect against infection, but will minimize the severity
of upper respiratory infections. Because there are over 65 types of Calici
virus, no vaccine will prevent disease in all situations.(6, 7 15, 19, 21)
Intranasal vaccines used in conjunction with parenteral vaccines may be
more effective at preventing the disease entirely(23-p239), and intranasal
vaccines will be safer.
A rare
side-effect to the intranasal vaccines is sneezing for one or two days
post-vaccination. This is normal and nothing to worry about. Because
intranasal vaccines produce an immunity of shorter duration, tri-annual
vaccination is recommended.
Vaccines not
Recommended For Cats
Chlamydia
or pneumonitis:
This is a rare ocular disease of cats and kittens accounting for less than
5% of upper respiratory infections in cats.(13, 15, 21) It is a mild easily
treated disease. The vaccination produces only a short (2 month) duration of
immunity.(19)
Reactions
to this vaccine can be serious including fever, loss of appetite,
polyarthritis or anaphylaxis. It is estimated by the AAFP that the reaction
rate to this vaccine is 3%. This vaccine is not recommended because the risk
outweighs the benefits. This vaccine is only useful in a cattery or multi-cat
household with an ongoing problem with chlamydia.
Feline
Infectious Peritonitis
Most kittens (85%) become infected with the non pathogenic Enteric Corona
virus during the first 3 months of life. This virus does not produce any
disease. The FeCoV very rarely mutates to the virulent, disease producing
FIP virus. Just like no two snow flakes are alike, no two FIP viruses are
alike. There is no cross protection by the vaccine between different
viruses. Therefore the vaccine cannot possibly work.
The
vaccine is labeled for use at 16 weeks. If the objective of the vaccine is
to prevent infection, there is no advantage to vaccination after the
infection has occurred.(21)
A report
by Dr. Fred Scott at Cornell University did not confirm the efficacy claims
of the manufacturer.(13, 15, 21)
In a
study at Texas A & M and in Dr. Scott's study, cats that were vaccinated and
developed FIP actually died faster from FIP than unvaccinated cats. This
suggests that the vaccine could actually enhance the disease caused by FIP
(vaccine enhanced disease). There is no good data to suggest that this
vaccine is effective.
The risks
and benefits of vaccination for FIP should be weighed carefully. Avoiding
over crowded and poor sanitation as well as avoiding exposure of kittens
less than 16 weeks of age to adult cats other than their mother is
recommended.
There is
no test that is specific for the FIP virus. All available tests will detect
normal FeCoV as well. There is no correlation between a high titer FIP Test
and FIP disease.
All 27
veterinary schools in North America do not recommend FIP vaccine or Testing.
.(13)
Bordetella
A new vaccine for feline bordetella has recently been introduced. Although
bordetella can cause serious infection in kittens, Dr. Wolfe of Texas A&M
University says that bordetella is a normal flora and does not likely cause
disease in adult cats. Dr. Lappin of Colorado State University agrees & says
that a review of the Colorado State medical records reveals not one case
diagnosed in 10 years. This vaccine is only applicable for kittens in a
shelter where the disease is a proven problem.
This
vaccine has been reported to cause sneezing in up to 15% of cats
vaccinated.
Giardia
Vaccine:
A newly introduced vaccine for Giardia has shown poor efficacy.
Immunologists say it would be necessary to produce secretory mucosal IGA
antibodies to protect against an intestinal parasite and a parenteral (injectable)
vaccine does not do this. Independent studies have failed to support the
efficacy of this vaccine.